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FEBS Lett 579, 1399-1404. Asuni AA, Boutajangout A, Quartermain D, Sigurdsson EM (2007) Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces mind pathology with related purposeful improvements. J Alzheimers Dis 15, 169-179. Kayed R, Jackson GR (2009) Prefilament tau species as likely targets for immunotherapy for Alzheimer disease and associated problems. J Alzheimers Dis 15, 157-168. Zilka N, Kontsekova E, Novak M (2008) Chaperone-like antibodies concentrating on misfolded tau protein: New vistas in the immunotherapy of neurodegenerative foldopathies. J Alzheimers Dis 26(Suppl 3), 147-157. Jensen JR, Cisek K, Honson NS, Kuret J (2011) Ligand polarizability contributes to tau fibril binding affinity. J Med Chem 55, 9170-9180. Jensen JR, Cisek K, Funk KE, Naphade S, Schafer KN, Kuret J (2011) Research towards tau imaging. Exp Gerontol 47, 723-733. Rachubinski AL, Crowley SK, Sladek Jr, Maclean KN, Bjugstad KB (2012) Effects of neonatal neural progenitor cell implantation on grownup neuroanatomy and cognition in the Ts65Dn model of Down syndrome.

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wild Ann Neurol 70, 353-361. Taupin P (2011) Neurogenesis, NSCs, pathogenesis and therapies for Alzheimer’s disease. Am J Alzheimer’s Dis Other Demen 24, 52-57. Taupin P (2009) Adult neurogenesis and the pathogenesis of Alzheimer’s condition. Exp Gerontol 35, 489502. Sugaya K, Brannen CL (2001) Stem mobile procedures for neuroreplacement therapy in Alzheimer’s disorder. Nat Chem Biol 3, 435. Sugaya K, Kwak YD, Ohmitsu O, Marutle A, Greig NH, Choumrina E (2007) Practical difficulties in stem cell treatment for Alzheimer’s disorder. J Neurochem 118, 658-667. Boutajangout A, Sigurdsson EM, Krishnamurthy PK (2011) Tau as a therapeutic focus on for Alzheimer’s illness. Exp Neurol 224, 472-485. Vana L, Kanaan NM, Ugwu IC, Wuu J, Mufson EJ, Binder LI (2011) Progression of tau pathology in cholinergic Basal forebrain neurons in mild cognitive impairment and Alzheimer’s sickness. Am J Pathol 179, 25332550. Patterson KR, Remmers C, Fu Y, Brooker S, Kanaan NM, Vana L, Ward S, Reyes JF, Philibert K, Glucksman MJ, Binder LI (2011) Characterization of prefibrillar Tau oligomers in vitro and in Alzheimer illness. Biochemistry 50, 5172-5181. Zhang W, Arteaga J, Cashion DK, Chen G, Gangadharmath U, Gomez LF, Kasi D, Lam C, Liang Q, Liu C, Mocharla VP, Mu F, Sinha A, Szardenings AK, Wang E, Walsh JC, Xia C, Yu C, Zhao T, Kolb HC (2012) A remarkably selective and specific PET tracer for imaging of tau pathologies.

Neurosci Lett 450, 136-141. Feng Z, Zhao G, Yu L (2009) Neural stem cells and Alzheimer’s illness: Challenges and hope. Taupin P (2009) Adult neurogenesis, neural stem cells and Alzheimer’s disease: Developments, limits, challenges and promises. Expert Opin Drug Discov 5, 921-925. Taupin P (2010) Aging and neurogenesis, a lesion from Alzheimer’s illness. Transl Res 156, 155160. Couillard-Despres S, Iglseder B, Aigner L (2011) Neurogenesis, cellular plasticity and cognition: The effects of stem cells in the grownup and getting old brain-a mini-evaluation. Curr Alzheimer Res 8, 666-677. Gu J, Sigurdsson EM (2011) Immunotherapy for tauopathies. 109 Waldau B, Shetty AK (2008) Behavior of neural stem cells in the Alzheimer brain. Stem Cells Dev 19, 629-633. Lee HJ, Lee JK, Lee H, Shin JW, Carter JE, Sakamoto T, Jin HK, Bae JS (2010) The therapeutic likely of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer’s disorder. Bioorg Med Chem 19, 5147-5154. Boimel M, Grigoriadis N, Lourbopoulos A, Haber E, Abramsky O, Rosenmann H (2010) Efficacy and safety of immunization Lover Assists With Hymen Check-Up And Drilling Of Virgin Chick phosphorylated tau from neurofibrillary tangles in mice. Am J Pathol 120, 282-291. Taniguchi T, Sumida M, Hiraoka S, Tomoo K, Kakehi T, Minoura K, Sugiyama S, Inaka K, Ishida T, Saito N, Tanaka C (2005) Effects of different anti-tau antibodies on tau fibrillogenesis: RTA-1 and RTA-2 counteract tau aggregation.

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